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KMID : 0882420090760050611
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Korean Journal of Medicine
2009 Volume.76 No. 5 p.611 ~ p.616
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A case of vincristine-induced polyneuropathy in an patient with acute leukemia
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Back Su-Young
Park Byeong-Bae
Park Dong-Won
Kim Joo-Hyoung
Jung Kyoung-Hee
Kim Hye-Young
Park So-Yeon
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Abstract
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When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We describe a 16-year-old girl with acute lymphoblastic leukemia that appeared to be complicated by vincristine-induced peripheral and cranial polyneuropathy after induction chemotherapy. She presented with right ptosis six weeks after the first dose of vincristine, and her neurological symptoms progressed to peripheral polyneuropathy. She recovered from these neurological symptoms over the next three months. Leukemic involvement of the nervous system and other neurological disorders could be excluded as potential causes of the neurological symptoms. This report shows that vincristine-induced neurotoxicity should be considered as a cause of cranial neuropathy that develops during the treatment of acute lymphoblastic leukemia.
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KEYWORD
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Vincristine, Neurotoxicity, Polyneuropathy
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